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Abstract #1779

Intraoperative Volatile Anesthetic Exposure Predicts Reduced Frontal Lobe Connectivity Compared to Dexmedetomidine in Infants with Congenital Heart Disease

Vincent Kyu Lee1, Phillip Adams2, Benjamin Meyers1, Lauren Dennis3, Nancy Beluk1, Tracy Baust4, Lucas Saenz4, Yulia Domnina4,5, Joan Sanchez de Toledo4,5, Vincent J Schmithorst1, and Ashok Panigrahy1,6

1Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2Anesthesiology, Children's Hospital of Pittsburgh UPMC, Pittsburgh, PA, United States, 3Science Technology and Mathematics, Regent University, Pittsburgh, PA, United States, 4Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, United States, 5Critical Care Medicine, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 6Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States

Anesthetic neurotoxicity in infants with repetitive exposure is a risk factors for adverse neurodevelopmental outcomes. Dexmedetomidine exposure is thought to have neuroprotective effects. We tested the hypothesis that intraoperative volatile anesthetic exposure is predictive of aberrant brain connectivity in the post-operative period in CHD infants, relative to dexmedetomidine exposure using DTI and BOLD imaging. Using both hypothesis driven and data driven approaches, as well as graph analysis we showed that Increased volatile anesthetic exposure in the intraoperative period is associated with reduced post-operative frontal brain connectivity in CHD infants, while DEX exposure was associated with metrics of improved brain connectivity.

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