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Abstract #1808

Amygdala dysfunction during negative emotional situation in Obsessive-Compulsive Disorder

Hyunsil Cha1, Sang Won Lee2, Kyung Eun Jang1, Hyejeong Choi1, Eunji Kim1, Moojin Yang1, Jiung Yang1, Moon Jung Hwang3, Huijin Song4, Seung Jae Lee2, and Yongmin Chang1,5

1Department of Medical & Biological Engineering, Kyungpook national university, Daegu, Republic of Korea, 2Department of Psychiatry, Kyungpook national university hospital, Daegu, Republic of Korea, 3GE Healthcare, Seoul, Republic of Korea, 4Biomedical Engineering Research, Kyungpook national university, Daegu, Republic of Korea, 5Department of Radiology and Molecular Medicine, Kyungpook national university, Daegu, Republic of Korea

We investigated brain activation in obsessive-compulsive disorder (OCD) patient using thought-action fusion (TAF) task to assess the influence of OCD symptom on amygdala response to the task. Within and between group analysis of close and neutral condition showed decreased amygdala activation in patients with OCD compared to healthy control.

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