White matter aberrations have been well documented in schizophrenia using diffusion tensor or weighted imaging, but the differences in myelin macrostructure morphology have not been extensively explored. Here we used multi-echo T2 (ME-T2) imaging to examine myelin content and axonal size and packing density in schizophrenia in white matter regions, specifically association, commissural, and projection fiber tracts. We demonstrate reduced myelin content as well as increased axonal packing density in association and projection tracts, which may contribute to neural dysconnectivity mechanisms underlying the neuropathology of schizophrenia.
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