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Abstract #1826

Increased functional connectivity between medial prefrontal cortex and nucleus accumbens in morphine craving rats

Hannes Michel Wiesner1, Shinho Cho1, Yi Zhang1, Erin Larson2, Mark J. Thomas3, Xiao-Hong Zhu1, and Wei Chen1

1CMRR, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, United States, 2MnDRIVE Optogenetics and Neuromodulation Core, Neuroscience Department, University of Minnesota Medical School, Minneapolis, MN, United States, 3Departments of Neuroscience and Psychology, University of Minnesota Medical School, Minneapolis, MN, United States

Morphine is a potent analgesic with a high addictive potential. In this study we have shown a difference in brain connectivity related to drug-seeking behavior involving key neural decision and reward systems using rs-fMRI. The finding contributes to a better understanding of the neural underpinnings of opioid addiction and could help in a better assessment of relapse risk in individuals.

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