Abstract #1835

Longitudinal structural white matter alterations in adolescents at risk for psychopathology: a Randomised Controlled Trial.

Stijn Michielse¹, Jindra Bakker¹, Iris Lange¹, Liesbet Goossens¹, Koen Schruers^1,2, Ritsaert Lieverse¹, Therese van Amelsvoort¹, Marieke Wichers³, Jim van Os^1,4,5, and Machteld Marcelis^1,6

¹Psychiatry & Neuropsychology, Maastricht University, Maastricht, Netherlands, ²Faculty of Psychology, University of Leuven, Leuven, Belgium, ³Department of Psychiatry, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Psychosis Studies, Institute of Psychiatry, King’s College London, London, United Kingdom, ⁵f. Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Institute for Mental Health Care, Eindhoven, Netherlands

This project is an RCT in 51 individuals with mild psychopathology randomly assigned to Acceptance and Commitment Therapy (ACT) or topic discussion group conditions. Participants underwent Diffusion Weighted Imaging (DWI), Experience Sampling Method (ESM) and a Community Assessment of Psychic Experiences (CAPE) questionnaire before and after intervention. Results show no differences between conditions after the intervention in the white matter (DWI) or the amount of psychotic experiences (CAPE). The suspicious mood ESM item showed was significantly changed due to ACT-intervention. Therefore white matter changes do not seem to occur, while mood changes as a result after 12 week intervention.

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