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Abstract #1838

SUBCORTICAL VOLUMETRIC CHANGES IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER: ROLE OF MRI

Mariia Viktorovna Rezakova1, Elena Andreevna Filimonova1, Khurshed J. Ibrogimov2, Olga Anatolevna Subbotina1, and Alexandr Vladimirovich Shevchenko1

1Stare Scientific-Research Institute of Physiology and Basic Medicine, Novosibirsk, Russian Federation, 2Novosibirsk State University, Novosibirsk, Russian Federation

We analyzed subcortical structures in patients with MDD (N=15) and control (N=15) using FreeSurfer. Patients with MDD had significantly lower left thalamus (p<0,01), left putamen (p<0,05), left hippocampus (p<0,05) and some hippocampal subfields volumes, relative to control. We found correlations (p<0,05) between patient’s age and putamen volume (r= -0,56), number of depressive episodes and molecular layer volume (r= -0,52). We didn’t reveal correlation between segmentation data and MDD severity.

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