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Abstract #1842

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia

Siyi Li1, Leah Rubin2, Li Yao1, and Su Lui1

1Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Psychiatry, Women's Mental Health Research Program,University of Illinois at Chicago, Chicago, IL, United States

Oxytocin (OT) and arginine vasopressin (AVP) exert sexually dimorphic effects on cognition and emotion processing in healthy individuals, and abnormalities in these neuroendocrine systems are observed in schizophrenia with a sex-dependent manner. Here we examined sex-dependent hormone associations with resting brain activity by applying resting-fMRI and their clinical associations in schizophrenia patients relative to healthy controls. We found that hormones differentially associate with brain networks, the sex-dependent alternation of hormone and brain activity are important for cognition and emotion processing in men and women with schizophrenia.

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