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Abstract #1848

Relevance of microglia receptor TREM2 for remyelination as revealed by multimodal MRI in the cuprizone mouse model

Anna E. Mechling1, Eva Mracsko1, Andreas Bruns1, Thomas Mueggler1, Irene Knuesel1, and Basil K√ľnnecke1

1NORD Discovery & Translational Area, Pharmaceutical research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Demyelination and ensuing axonal damage are hallmarks of numerous neurodegenerative disorders. Novel treatment strategies seek to enhance remyelination and axonal recovery through acceleration of myelin debris clearance by phagocytic microglia. TREM2 is a receptor expressed by microglia that has been implicated in the regulation of phagocytosis, migration and anti-inflammatory activity. Here, we further elucidated the role of TREM2 in de- and remyelination processes by means of multiparametric in vivo MRI. We combined a TREM2 loss-of-function mouse model with cuprizone feeding as an accepted model for demyelination. Deficiency of TREM2 leads to progressive structural disintegration and absence of proper remyelination.

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