Abstract #1851

Dynamic Sensitivity of 3D Ultrashort Echo Time (UTE) Cones Imaging for Myelin Concentration Quantification

Adam Cory Searleman¹, Shu-Juan Fan^1,2, Yajun Ma¹, Eric Y Chang^1,3, and Jiang Du¹

¹Radiology, University of California San Diego, La Jolla, CA, United States, ²Radiology, University of California, San Francisco, San Francisco, CA, United States, ³Radiology, VA San Diego Healthcare System, San Diego, CA, United States

Quantification of myelin has the potential to be used as a specific biomarker for demyelinating diseases of the nervous system such as multiple sclerosis. Ultrashort echo time (UTE) MRI has been shown to be able to directly detect signal from myelin protons, but the dynamic sensitivity of the 3D UTE Cones sequence remains unclear. This study examined the correlation between 3D UTE Cones signal intensities and different concentrations of myelin extract in D₂O, and found a strong linear correlation up to a myelin concentration of 24% (w/v).

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