Abstract #1862

mcDESPOT-derived measurements are sensitive to differences in myelin content and thickness in the corpus callosum of neuromyelitis optica patients and healthy controls

Shawna Abel¹, Irene Vavasour², Lisa Lee¹, Roger Tam², Cornelia Laule², Robert Carruthers¹, Anthony Traboulsee¹, Anna Combes³, and Shannon Kolind¹

¹Neurology, University of British Columbia, Vancouver, BC, Canada, ²Radiology, University of British Columbia, Vancouver, BC, Canada, ³Neuroimaging, King's College London, London, United Kingdom

Histological studies suggest that white matter microstructure varies across different subregions of the corpus callosum (CC). We used mcDESPOT-derived measures to examine myelin content and thickness in vivo in 3 subregions of the CC in healthy controls (HC) and individuals with neuromyelitis optica spectrum disorder (NMOSD). Differences in both myelin content and thickness were observed in different subregions of the CC in HC. Myelin content was decreased in posterior CC in NMOSD relative to HC. mcDESPOT-derived myelin measurements are sensitive to differences in white matter microstructure and can be used to investigate the underlying pathology contributing to demyelinating diseases.

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