The purpose of his work was to characterize the Posterior Limb of the Internal Capsule (PLIC) of subacute stroke patients using both DTI and NODDI approaches to investigate microstructural changes occurring in the lesioned with respect to the unlesioned hemisphere. Six patients having a brain damage involving the Corticospinal Tract (CST) were enrolled. MRI was carried out on a 3T scanner about 14 days after stroke occurrence. DTI and NODDI analysis showed CST alterations in subacute stroke patients. FA and ODI were the only parameters that underwent significant modifications in PLIC regions.