Inhomogeneous magnetization transfer (ihMT) has been recent developed and has shown promise for myelin-specific imaging. The abnormal lipid pattern in the myelin of the white matter has been observed and could play an important role on ischemic lesion after stroke. The aim of this study was to investigate the myelin change within ischemic lesions using ihMT. In our presentative case, the abnormal area on DWI appears larger than that on ihMT. The difference may result from heterogeneous tissue characteristic in acute ischemic brain, which might evolve with the time after symptom onset and indicate a different clinical outcome.