Postural Instability Gait Disorder (PIGD), a Parkinson's Disease (PD) motor subtype, progresses rapidly with a higher prevalence of neurobehavioural changes. Using automated deep grey nuclear tissue classification combined with atlas-based segmentation, we investigated the performance of resulting estimated lesion load to aid differential diagnosis. Caudate lesion load in PIGD and idiopathic PD subtypes correlated with clinical balance and gait assessment. Combining caudate with abnormal white matter volumetric characterization further improved the discriminative power and could potentially support differential diagnosis of PD.
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