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Abstract #1929

Brain morphological changes in early-stage Parkinson’s disease

Lanbo Wang1,2, Xishan Ye1, Thyagarajan Subramanian3,4, Qing X Yang1,5, and Jianli Wang1

1Radiology, Penn State University College of Medicine, Hershey, PA, United States, 2Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China, 3Neurology, Penn State University College of Medicine, Hershey, PA, United States, 4Neural & Behavioral Sciences, Penn State University College of Medicine, Hershey, PA, United States, 5Neurosurgery, Penn State University College of Medicine, Hershey, PA, United States

At disease onset clinically, the motor symptoms and signs are usually asymmetric or unilateral in majority of Parkinson’s disease (PD) patients. When disease progresses to a later stage, the asymmetry becomes less significant. The cause of this asymmetry, and the relationship between functional deficits and the structural changes in the brain are not clear. In this study, we investigated the morphological changes in the brain hemispheres corresponding to the early-onset and late-onset body sides through a longitudinal study on 24 early-stage PD patients. Significant atrophy was observed in the motor cortex and basal ganglia nuclei.

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