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Abstract #1931

Functional brain connectome architecture in a large cohort of Parkinson’s disease patients

Silvia Basaia1, Federica Agosta1, Homa Zahedmanesh1,2, Tanja Stojkovic3, Vladana Markovic3, Iva Stankovic3, Igor Petrovic3, Elka Stefanova3, Vladimir Kostic3, and Massimo Filippi1,4

1Neuroimaging Research Unit, INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 2Department of Electronics, Information, and Bioengineering (DEIB), Politecnico di Milano, Milano, Italy, 3Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Yugoslavia, 4Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

In this study, we investigated functional neural pathway organization in patients with Parkinson’s disease (PD) using advanced network-based techniques. At the regional network level, compared to controls, PD groups showed decreased functional connectivity within basal ganglia/sensorimotor network and parietal regions. Compared to early PD cases, mild-to-severe PD patients were characterized by a greater involvement of basal ganglia/sensorimotor networks. This study suggests that graph analysis and connectomics might represent a powerful approach to understand the pathophysiological process across different stages of the disease.

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