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Abstract #1934

Baseline Symptoms and Basal Forebrain Volume Predict Future Psychosis in Early Parkinson Disease

Jamie Blair1, Matthew Barrett2, Scott Sperling2, Mark Smolkin3, and T. Jason Druzgal1

1Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, 2Neurology, University of Virginia, Charlottesville, VA, United States, 3Public Health Services, University of Virginia, Charlottesville, VA, United States

Psychosis is a common neuropsychiatric symptom of Parkinson’s disease, and can serve as a clinical marker of advanced disease. Our study aimed to investigate the characteristics of psychosis in a longitudinal PD cohort, to verify baseline clinical risk factors for future psychotic symptoms in de novo PD patients, and to evaluate the relationship between baseline gray matter density in the nucleus basalis of Meynert and future psychotic symptoms in PD. We found lower NBM density at baseline to be associated with increased psychotic symptom burden compared to controls, suggesting utility for the NBM as a neuroimaging biomarker for advanced PD.

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