Abstract #1940

BOLD responses to light stimulus frequency in the rat visual pathway reveal profound effects of Parkinson’s disease in the Superior Colliculus

Emmanuelle Bellot¹, Arnaud Pautrat¹, Yassamine Rahmani Bouzina¹, Nora Collomb², Olivier Montigon², Véronique Coizet¹, and Michel Dojat¹

¹Grenoble Institut of Neurosciences, Inserm U1216, La Tronche, France, ²UMS Irmage, La Tronche, France

Sensory disorders are associated with Parkinson Disease (PD) at an early stage. We explored with fMRI the visual pathway response to light stimulus frequency in PD rat models. Activation of the Superior Colliculus (SC) was exacerbated at low frequency (1-3%) and rapidly saturated compared to controls. These results confirm the possible role of SC as an early biomarker of the disease.

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