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Abstract #1942

Iron Deposition Quantification in Patients with Parkinson’s Disease by Quantitative Susceptibility Mapping

Zhangxuan Hu1, Yuhui Xiong1, Xuesong Li2, Rongsong Zhou3, Suhua Miao3, Le He1, Yu Ma3, and Hua Guo1

1Biomedical Engineering, Tsinghua University, Beijing, China, 2School of Computer Science and Technology, Beijing Insitute of Technology, Beijing, China, 3Tsinghua University Yuquan Hospital, Beijing, China

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders worldwide. This study explores the relationships between iron accumulation in different nucleus, including red nucleus (RN), caudate nucleus (CN), global pallidus (GP), putamen (PUT), and the severity of PD, which is characterized by the Unified Parkinson’s Disease Rating Scale (UPDRS)-III. Significant bilateral difference was found in RN only. Significant correlations were found in bilateral GPe, PUT, RN, and contralateral GPi, which can serves as an evidence that iron deposition can be an important biomarker for the severity of PD.

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