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Abstract #1943

Use of Functional MRI to assess the differences of STN and GPI Deep Brain Stimulation in Parkinson Disease

Marisa DiMarzio1, Ileana Hancu2, Eric Fiveland2, Julia Prusik3, Radhika Madhavan4, Suresh Joel4, Michael Gillogly3, Jeffery Ashe2, Tanweer Rashid1, Jennifer Durphy5, Roy Hwang3, and Julie Pilitsis1,3

1Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, United States, 2GE Global Research Center, Niskayuna, NY, United States, 3Neurosurgery, Albany Medical College, Albany, NY, United States, 4GE Global Research Center, Bangalore, India, 5Neurology, Albany Medical College, Albany, NY, United States

Deep brain stimulation (DBS) of both the subthalamic nucleus (STN) and globus pallidus interna (GPi) are well-recognized effective treatments for Parkinson’s disease (PD). The mechanism of DBS and network responses produced by stimulation of these targets remains unknown. Conditional labeling of DBS now allows fMRI to be performed in the ON state. We examine whether GPI DBS and STN DBS affect blood oxygen level dependent (BOLD) brain activation/deactivation patterns similarly. Results show that both types of DBS activate the thalamus and deactivate the primary motor cortex; while the STN cohort showed activation in the cerebellum, an opposite effect was apparent in the GPi cohort.

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