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Abstract #1990

A new texture-based method for assessing high angular diffusion MRI from patients with multiple sclerosis

Zahra Hosseinpour1, Olayinka Oladosu2, Wei-qiao Liu2, Bruce G Pike2, Luanne M Metz2, and Yunyan Zhang2

1Schulich school of engineering, University of Calgary, Calgary, AB, Canada, 2University of Calgary, Calgary, AB, Canada

The capacity of high angular resolution diffusion MRI to detect subtle pathology in multiple sclerosis (MS) patients can be enhanced when combined with image texture analysis techniques. This study proposes a new voxel-based analysis of diffusion image texture including entropy and angular second moment (ASM, homogeneity), and 45 direction-values per voxel. Results show that while all diffusion maps have differences between lesions and control tissue, both diffusion entropy and ASM maps have better contrast than the classical maps of fractional anisotropy. This new approach may enhance our ability in detecting subtle nerve fiber tract integrity.

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