Meeting Banner
Abstract #2006

Regional brain iron accumulation in an Alzheimer’s mouse model fed lipophilic iron

Douglas G Peters1, Carson J Purnell1, Qing X Yang2, James R Connor1, and Mark D Meadowcroft1,2

1Neurosurgery, The Pennsylvania State University - College of Medicine, Hershey, PA, United States, 2Radiology, The Pennsylvania State University - College of Medicine, Hershey, PA, United States

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized pathologically by amyloid beta (Aβ) deposition, microgliosis, and iron dyshomeostasis. The goal of this work was to observe how brain iron levels temporally influence Aβ plaque formation, plaque iron concentration, and microgliosis. Humanized APPNL-G-F knock-in and control mice were fed either lipophilic iron compound 3,5,5-trimethylhexanoyl ferrocene (TMHF), normal, or iron deficient diets for twelve months. Increased brain iron was observed in the olfactory, frontal and hippocampal regions and was associated with increased plaque-iron loading and microglial iron inclusions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here