Correlation analysis between the gray matter volumes obtained with two different imaging sequences and the cognitive decline in Apolipoprotein E ε4 carrier subjects

To evaluate the association between GMV loss and cognitive decline in the APOE e4 carriers and to investigate alterations of GMV, MPRAGE and DIR images were acquired from 72 subjects (51 noncarriers, 21 carriers). Voxel- and ROI-based analyses were performed to evaluate the association between GMV loss and the MMSE score and to do the group differences of GMV for each sequence. GMV of carriers was positively correlated with the MMSE score for both sequences. DIR can be effective for identifying GMV loss in the carriers and may be useful to evaluate GMV changes in the early stage of dementia.