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Abstract #2026

Changes in Functional and Structural Brain Connectome Along the Alzheimer’s Disease Continuum

Federica Agosta1, Silvia Basaia1, Elisa Canu1, Francesca Imperiale1, Giuseppe Magnani2, Monica Falautano2, Giancarlo Comi2, Andrea Falini3, and Massimo Filippi1,2

1Neuroimaging Research Unit, INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 2Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 3Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

We investigated structural and functional brain network architecture in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI); and assessed the relationship between healthy brain network functional connectivity and the topography of brain atrophy in patients along the AD continuum. Structural connectivity alterations distinguished MCI who converted to AD from those who did not. Brain regions most strongly connected with the disease-epicenter (left hippocampus) in the healthy functional connectome were also the most atrophic in both AD and converters MCI. Graph theoretical analysis provides insight on how neurodegeneration propagates across the human brain in the early phase of AD.

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