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Abstract #2074

Nutritional intervention for developmental brain damage: neuroprotection with Lactoferrin following intrauterine growth restriction.

Yohan van de Looij1,2,3, Camille Larpin1, Petra S Hüppi1, and Stéphane V Sizonenko1

1Service développement et croissance, Université de Genève, Geneva, Switzerland, 2Laboratoire d'imagerie fonctionnelle et métabolique, Ecole polytechnique fédérale de Lausanne, Lausanne, Switzerland, 3Institut translationnel d'imagerie moléculaire, Université de Genève, Geneva, Switzerland

Lactoferrin (Lf) is an iron-binding glycoprotein secreted in milk known as antioxidant, antimicrobial and anti-inflammatory. Infants exposed to adverse prenatal conditions of intrauterine growth restriction (IUGR), are at high risk for neurological morbidities. The aim of this work was to assess neuroprotective effect of Lf on brain microstructure by using diffusion imaging and NODDI model at 9.4T in a model of 50% gestational caloric restriction. Diffusion MRI derived parameters changes following IUGR were partially restored in the Lf supplemented group, providing evidence of a neuroprotective effect.

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