Abstract #2076

The Aging Brain: Cerebrovascular responses to CO2.

Larissa McKetton¹, Olivia Sobczyk², Julien Poublanc¹, Kevin Sam^2,3, Adrian P. Crawley¹, Lakshmikumar Venkat Raghavan⁴, James Duffin^4,5, Joseph A. Fisher^2,4,5, and David J. Mikulis^4,5

¹Division of Neuroradiology, Joint Department of Medical Imaging, University Health Network, Toronto, ON, Canada, ²Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ³The Russell H. Morgan Department of Radiology & Radiological Science, The John Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Anaesthesia and Pain Management, University Health Network, Toronto, ON, Canada, ⁵Department of Physiology, University of Toronto, Toronto, ON, Canada

Measures of cerebrovascular reactivity (CVR) are used to judge the health of the brain vasculature. We report the use of several different analyses of BOLD responses to CO₂ to provide a number of metrics for various aspects of CVR. To assess possible differences in these metrics with age, we compiled atlases reflecting voxel-wise means and standard deviations for different age ranges and compared them.

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