Abstract #2078

Altered Intrinsic Brain Activity and Memory Function Improvement in Patients with End-Stage Renal Disease During A Single Dialysis Session

Peng Li¹, Dun Ding², Xueying Ma², Huawen Zhang¹, Jixin Liu³, and Ming Zhang²

¹Department of Medical Imaging, NO.215 Hospital of Shaanxi Nuclear Industry, Xianyang, China, ²Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China, ³Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China

The underlying neural mechanisms of the memory deficits in end-stage renal disease patients with dialysis treatment are poorly understood. Here we analyzed the resting-state brain activity changes and the related memory improvement by using mALFF and ReHo methods before dialysis (T1_pre-dialysis) and after 24 hours (T2_{post-dialysis}). The results indicated that regional spontaneous activity changes of the DLPFC were related with memory improvement after a single dialysis treatment, which may provide insight into the effect of hemodialysis on changes of brain function and cognitive impairments.

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