Although transcranial direct current stimulation (tDCS) offers a therapeutic solution in many neurological diseases, it is still poorly understood how tDCS works underlying neuronal activity in real time. This work was to investigate the real-time tDCS (during stimulation) neuronal response measured with oxygen metabolic MRI. We found cerebral metabolic rate of oxygen (CMRO2) increased during tDCS as compared to sham and immediately reduced when tDCS was turned off but remained at slightly higher level than pre-tDCS. The results strongly support our hypothesis that electric current stimulation can induce neuronal activity and CMRO2 increase.
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