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Abstract #2119

Protective effect of high creatine diet during chronic hepatic encephalopathy in young rats, an in vivo longitudinal 1H and 31P MRS study

Veronika Rackayova1, Olivier Braissant2, Dario Sessa3, Stefanita Mitrea4, Valerie McLin3, Rolf Gruetter4, and Cristina Cudalbu4

1Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Neurometabolic Unit, Service of Clinical Chemistry, University Hospital of Lausanne, Lausanne, Switzerland, 3Swiss Center for Liver Disease in Children, University Hospitals Geneva, Geneva, Switzerland, 4Centre d’Imagerie Biomédicale (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Chronic hepatic encephalopathy(CHE) is a serious neuropsychiatric disease with altered neurological status and changes in brain metabolites (among others, decrease in brain tCr). If CHE is acquired in childhood these conditions might perturb normal brain development. Our aim was to test whether oral Cr supplementation dampens the neurometabolic changes observed in CHE in a longitudinal model of chronic liver disease in young rats. Using in vivo longitudinal brain 1H and 31P-MRS, we showed rescued tCr levels, enhanced energy metabolism (restoration of ATP), improved antioxidant capacity (increased Asc), positive effect on phospholipid metabolism and smaller increase in Gln (marker of CHE).

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