In diffuse intrinsic pontine glioma, the mutations of histones (H3.1 versus H3.3) are correlated with patient survival. A new method to compute radiomic features free of tumor volume effect was applied to four structural MR modalities and patients were classified according to histone mutation. The tumor was scanned by a 5 mm radius sphere and textural indices were computed inside each position. A total of 37 features calculated from T2w-FLAIR yielded an area under the Receiver Operating Characteristics curve greater than 0.85. T2w-FLAIR appears to be the most informative modality to predict mutation type.