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Abstract #2140

Robust Quantification of Changes in Arterial Cerebral Vasculature Post Radiation Therapy in Pediatric Brain Tumor Survivors

Sivakami Avadiappan1, Sam Payabvash1, Angela Jakary1, Erin Felton2, Melanie Morrison1, Christopher P Hess1,2, Sabine Mueller2,3, and Janine M Lupo1

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Neurology, University of California, San Francisco, San Francisco, CA, United States, 3Department of Neurological Surgery, University of California, San Francisco, San Franciso, CA, United States

With the improved long-term survival of children with brain tumors, understanding the late effects of their therapy on small arterioles is of great importance. We developed a method for robust segmentation of arteries and quantification of their thickness using TOF-MRA at 7T and estimated the vessel radii distribution in irradiated patients compared to controls. Radiation-induced damage to the microvasculature resulted in a higher fraction of small vessels observed with time from radiation therapy, likely due to vessel thinning.

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