Abstract #2158

Comparing pCASL CBF measurements between 3D-GraSE and 2D-EPI on 1.5T and 3T systems

Koen P.A. Baas^1,2, Henri J.M.M. Mutsaerts^2,3, Jan Petr^3,4, Joost P.A. Kuijer², and Kim C.C. van de Ven¹

¹BIU MR, Philips, Best, Netherlands, ²VUmc, Amsterdam, Netherlands, ³Kate Gleason College of Engineering, Rochester Institute of Technology (RIT), Rochester, NY, United States, ⁴PET Center, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

We have compared CBF value agreement in healthy subjects across two readouts, 3D-GraSE and 2D-EPI, and two field strengths, 1.5T and 3T, and investigated with which acquisition parameters we can reach the best agreement. Significantly higher GM CBF was observed with the 2D-EPI readout compared to the 3D-GraSE readout with equivalent acquisition voxel size (p < 0.005 for 1.5T and p < 0.05 for 3T). Better agreement was observed between 3D-GraSE and 2D-EPI on 3T systems when the resolution of the 3D-GraSE readout was increased to match the effective resolution to the 2D-EPI scan (ICC = 0.772 and ICC = 0.932 respectively).

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