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Abstract #2165

Blood-Brain Partition Coefficient Correction Improves Gray-White Matter Contrast in Blood Flow Measurement in Mice

Scott William Thalman1, David Powell1,2, and Ai-Ling Lin1,3

1Biomedical Engineering, University of Kentucky, Lexington, KY, United States, 2Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, United States, 3Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United States

The blood-brain partition coefficient (BBPC) is a tissue-specific parameter important in quantifying cerebral blood flow (CBF), but regional differences in BBPC are commonly ignored. Using an accelerated calibrated proton density imaging technique we measure BBPC directly, enabling a voxel-wise correction of CBF maps derived from arterial spin labeling acquisitions. We measure an elevated BBPC in the cortex (0.99mL/g) relative to the corpus callosum (0.93mL/g) and the hippocampus (0.95mL/g), and demonstrate that BBPC-correction improves gray-white matter contrast in CBF maps by 15% in the cortex and 7% in the hippocampus.

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