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Abstract #2180

Evaluation of dynamic DCE-MRI of the temporomandibular joint

Ondrej Macicek1, Erling Andersen2, Oskar Angenete3,4, Thomas Augdal5, Karen Rosendahl6,7, Radovan Jirik1, and Renate Grüner8,9

1The Czech Academy of Sciences, Institute of Scientific Instruments, Brno, Czech Republic, 2Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway, 3Department of Radiology and Nuclear Medicine, St Olav Hospital HF, Trondheim, Norway, 4Department of Circulation and Medical imaging, Norwegian University of Science and Technology, Faculty of Medicine, Trondheim, Norway, 5Department of Radiology, University Hospital of North Norway, Tromsø, Norway, 6Dept of Radiology, Haukeland University Hospital, Bergen, Norway, 7Dept of Clinical Sciences, University of Bergen, Bergen, Norway, 8Department of Radiology, Haukeland University Hospital, Bergen, Norway, 9Dept Physics and Technology, University of Bergen, Bergen, Norway

The feasibility of DCE-MRI as a tool to investigate perfusion of temporomandibular joints (TMJs) in case of Juvenile Idiopathic Arthritis (JIA) in children is investigated. The hypothesis in this current study is that inflammation is associated with increased vascularity and is the origin of experienced pain. Contrary to previous studies, high temporal resolution (~4s) dynamic DCE-MRI using advanced pharmacokinetic models are for the first time applied when imaging the TMJ in JIA children aged 6-15. Results of deconvolution show that there is a difference in perfusion parameters between affected and unaffected patients, especially when permeability-surface area product (PS) and blood plasma flow (Fp) parameters are combined.

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