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Abstract #2229

Optimization and acceleration of Selective Inversion Recovery imaging for practical whole-brain quantitative Magnetization Transfer measurements

Matthew J Cronin1, Junzhong Zhu1, Daniel Gochberg1, and Richard D Dortch1

1Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States

Selective inversion recovery quantitative magnetization transfer (SIR-qMT) imaging offers increased efficiency relative to conventional pulsed-saturation qMT due to its ability to quantify MT parameters without the need for independent estimates of B0, B1+, and T1. Despite this, qMT acquisition at a reasonable resolution over a large field of view remains prohibitively time consuming. Here, we employ an optimised acquisition strategy and accelerated readouts to acquire whole-brain SIR-qMT data at 2 x 2 x 3 mm3 resolution in ~10 minutes; opening the door to qMT imaging on a time scale practical for clinical application.

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