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Abstract #2247

gagCEST on patients with focal knee cartilage defects

Markus M. Schreiner1,2, Vladimir Mlynarik2,3, Stefan Zbyn2,4, Vladimir Juras2, Pavol Szomolanyi2, Didier Laurent5, Celeste Scotti5, Harry Haber5, and Siegfried Trattnig2,3

1Department of Orthopedics, Medical University of Vienna, Vienna, Austria, 2High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 3CD Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 4Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 5Novartis Institutes for Biomedical Research, Basel, Switzerland

The gagCEST technique is a promising tool for determining concentration of glycosaminoglycans in articular cartilage. In this study, the performance of gagCEST in a group of patients with ICRS grade I-II knee cartilage defects was investigated. It was found that the method gives significantly different mean MTRasym values for cartilage defects, normal weight-bearing and normal non-weight-bearing femoral cartilage. The clinical use of the gagCEST technique is currently limited by its long measurement time and sensitivity to patient motion.

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