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Abstract #2270

Aqueous and Non-aqueous T1 relaxation in brain under six diverse initial conditions

Alan Manning1, Carl Michal1, and Alex MacKay1,2

1Physics, University of British Columbia, Vancouver, BC, Canada, 2Radiology, University of British Columbia, Vancouver, BC, Canada

A consistent view of T1 relaxation in white matter remains elusive. We use an NMR spectrometer to observe white matter T1 relaxation behavior in both aqueous and non-aqueous protons following six diverse initial magnetizations. The data is analyzed in the context of both an unrestricted and restricted four pool model. We show how the observed multi-component T1 relaxation behavior depends sensitively on the initial conditions of the different pools, suggesting that great care must be taken in interpreting T1 relaxation measurements.

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