In vivo magnetic resonance elastography (MRE) experiments on the 5XFAD Alzheimer’s disease (AD) mouse model were conducted. The AD and Control mice were in the age group of ~1 month (n = 2 for both) and 3~4 months (n = 5 for both). Median stiffness values were measured over different regions of the brain. The overall brain tissue was stiffer in the disease model when compared to the control, with results being significant at the 3~4-month time point. Further experiments are underway at the 1-month time-point for conclusive age-based comparisons.