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Abstract #2281

Dynamic Contrast Enhanced DWI in a split dynamic framework

Tryggve Holck Storås1, Endre Grøvik1, Kjell-Inge Gjesdal2,3, Sebastian Meltzer4,5, and Kathrine Røe Redalen4,6

1Diagnostic Physics,KRN, Oslo Universityhospital, Oslo, Norway, 2Department of Radiology, Akershus University Hospital, Lørenskog, Norway, 3Sunnmøre MR-klinikk, Ålesund, Norway, 4Department of Oncology, Akershus University Hospital, Lørenskog, Norway, 5Faculty of Medicine, University of Oslo, Olso, Norway, 6Department of Physics, NTNU, Trondheim, Norway

Most MRI contrast agents distributes extracellular only. If the extracellular water signal is suppressed by diffusion weighting the short ranged T1-relaxation effect of a the contrast agent will be solely through water exchange through the cell membrane. In this paper we describe the implementation of a dynamic contrast enhanced diffusion weighted acquisition facilitating the study of diffusion weighting on the relaxivity of contrast agents. This is all done within a Split Dynamic framework allowing for this study to be performed without sacrificing assessment of the established pharmacokinetic parameters.

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