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Abstract #2303

Brain activity and connectivity changes in response to glucose ingestion

Anna M van Opstal1, Anne Hafkemeijer1,2,3, Annette van den Berg-Huysmans1, Marco Hoeksma4, Cor Blonk4, Hanno Pijl5, Serge A.R.B Rombouts1,2,3, and Jeroen van der Grond1

1Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Methodology and Statistics, Institute of Psychology, Leiden, Netherlands, 3Leiden Institute for Brain and Cognition (LIBC), Leiden, Netherlands, 4Unilever Research & Development, Vlaardingen, Netherlands, 5Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands

Understanding of functional brain responses yields insights into satiety signaling, nutrient sensing, energy seeking and feeding behavior. The current aim was to determine normal whole brain functional responses to the ingestion of glucose in healthy normal weight subjects using BOLD signal, network connectivity and Eigen vector centrality functional MRI analysis approaches. Our results show that ingestion of glucose in a fasted state leads to deactivation and decreased connectivity, which can be associated with satiation and reward effects in the brain and a decrease in energy seeking. In contrast, drinking plain water leads to activation and increased centrality and connectivity.

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