The aims of this study are to reveal the underlying inhibitory mechanism of a compound against the chemokine signal, based on targeted protein structures, and to evaluate the analgesic effect on allodynia-specific responses in a rat chronic pain model, with our BOLD-fMRI-based pain evaluation system using a green laser. An NMR titration analysis demonstrated that the compound strongly binds to the chemokine receptor-binding protein. BOLD-fMRI revealed that the allodynia-specific responses were suppressed by the administration of the compound, in a similar manner to the existing analgesic, pregabalin, with a completely different mechanism of action from that of the compound.
This abstract and the presentation materials are available to members only; a login is required.