Chronic pain disorders are associated with high prevalence of depression which points to a link between two pathologies; although the underlying mechanisms remain elusive. As a translational approach, preclinical MR imaging offers a unique opportunity to reliably establish causal relations between the pathological conditions and brain function in vivo. In this study, we used a mouse model of neuropathic pain to investigate affective consequences of chronic pain. We performed behavioural assessments as well as resting-state fMRI and our results show a remodelling of functional connectivity in regions belonging to default-mode network and the reward system in mice with pain-induced depression.
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