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Abstract #2351

Diaschisis of The Language Network in Resting State fMRI Functional Connectivity of Post-Stroke Chronic Aphasia

Kwan-Jin Jung1 and Jacquie Kurland2

1Human Magnetic Resonance Center, University of Massachusetts Amherst, Amherst, MA, United States, 2Department of Communication Disorders, University of Massachusetts Amherst, Amherst, MA, United States

Functional connectivity (FC) of intrinsic networks was compared between two groups: healthy controls and post-stroke aphasia, using resting state fMRI. While the FC of auditory, motor, and default mode networks were preserved, FC of the language network was disrupted in the aphasia group. The aphasia group showed left ipsilateral frontal FC from the Broca area but not from the Wernicke area. Similarly, the aphasia group showed left ipsilateral temporo-parietal FC from the Wernicke area but not from the Broca area. Thus, a clear picture of diaschisis, not just structural disruption, was revealed in the FC of the aphasia group.

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