Synaptic transmission is well known to be reduced during sleep, and yet very little is known about the extent to which the various stages of sleep affect neurometabolism. Here, we measured whole-brain CMRO2 in test subjects by means of the OxFlow technique while collecting data continuously for a period of 30 minutes, first during wakefulness and, in a second set of experiments, during sleep and subsequent arousal. During wakefulness CMRO2 was stable (average CV~7%). Following onset of sleep there was a rapid decrease in CMRO2 by up to 25%, along with increased SvO2 but almost unaltered CBF.
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