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Abstract #2365

Information content carried by resting-state BOLD fMRI signals reduces differentially in sensory and memory compared with cognitive systems in MCS and UWS patients

Xiaolin Liu1, Xinhuai Wu2, Shanshan Chen3, Lubin Wang3, Bing Wu2, Yituo Wang3, Mingmei Ge2, Zhan Xu1, B. Douglas Ward1, Shi-Jiang Li1, and Zheng Yang3

1Medical College of Wisconsin, Milwaukee, WI, United States, 2Army General Hospital, Beijing, China, 3Beijing Institute of Basic Medical Sciences, Beijing, China

How brain injuries affect the information content carried by signals of brain imaging modalities in patients with consciousness disorders has received little attention. We proposed a novel principal-components-analysis-based approach to quantify regional information content in patients in a minimally conscious state (MCS) and with unresponsive wakefulness syndrome (UWS). We show a reduction of regional information content in both patient populations. Importantly, our analyses revealed differential patterns in the reduction of information content in the sensory and memory compared with high-order cognitive systems in MCS and UWS; such observations are consistent with the clinical symptoms in the two DOC patient populations.

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