Abstract #2380

Comparing cortical layer activation using gradient echo with phase regression and spin echo in the human visual cortex

Olivia W Stanley^1,2, Alan B Kuurstra², L Martyn Klassen^1,2, Ravi S Menon^1,2, and Joseph S Gati^1,2

¹Medical Biophysics, The University of Western Ontario, London, ON, Canada, ²Centre for Functional and Metabolic Mapping, The University of Western Ontario, London, ON, Canada

High resolution fMRI sequence selection is often a compromise between specificity to tissue (SE-EPI) and sensitivity to the BOLD effect (GE-EPI). Our work compared the laminar activation profiles of SE-EPI and GE-EPI once phase regression based macrovascular filtering has been applied. We demonstrated that GE-EPI with macrovascular filtering produces a laminar profile more similar to SE-EPI than GE-EPI without filtering. This shows that GE-EPI could be used for high resolution imaging and achieve a more sensitive profile when phase regression is included.

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