Differential expression of lipid metabolism-related proteins was recently
reported in breast cancer patients. In this retrospective MR spectroscopy (MRS)
study, the spectral lipid profile was assessed in breast cancer patients with
malignant and benign lesions. Single-voxel MRS data from 176 breast lesions was
analyzed to quantify multiple lipid metabolite concentrations using LCModel. Lipid peak analysis
highlighted significant differences in lipid
metabolite concentrations with significantly low concentrations in
malignant compared to benign lesions and in luminal cancers compared to other molecular
subtypes. MRS-based lipid metabolite profile
may provide a valuable tool for breast cancer diagnosis.
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