Xe-129 in the barrier and red blood cells could be separated by the dissolved-phase (DP) Xe-129 MRI with radial sampling strategy. However, the number of the RF pulse was usually large and thus resulted in long acquisition time. An MRI strategy in the Cartesian coordinate has been used to for high-resolution rodent lung imaging of He-3 in the airspace. The concept was introduced into fast acquisition of the DP Xe-129 in the human lung with the multi-point Dixon method. The number of the RF pulse reduced and the results of TP/Gas and RBC/Gas agreed with the previous study.