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Abstract #2458

The Impact of Inspiration Levels on the Repeatability of Quantitative Pulmonary Perfusion DCE-MRI in Patients with Chronic Obstructive Pulmonary Disease and Cystic Fibrosis

Marilisa Schiwek1,2, Frank Risse1, Simon M. F. Triphan2,3, Monika Eichinger2,3,4, Sabine Wege5, Mirjam Stahl3,6, Olaf Sommerburg3,6, Marcus A. Mall3,6,7, Hans-Ulrich Kauczor2,3,4, Michael U. Puderbach2,3,4,8, Ralf Eberhardt5, Claus P. Heussel2,3,4, Gudula Heussel2,3,4, and Mark O. Wielp├╝tz2,3,4

1Transl. Medicine + Clin. Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, 2Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany, 3Translational Lung Research Center Heidelberg (TLRC), German Lung Research Center (DZL), Heidelberg, Germany, 4Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at the University Hospital of Heidelberg, Heidelberg, Germany, 5Pulmonology and Respiratory Medicine, Thoraxklinik at the University Hospital of Heidelberg, Heidelberg, Germany, 6Pediatric Pulmonology & Allergy and Cystic Fibrosis Center, Pediatrics, University of Heidelberg, Heidelberg, Germany, 7Translational Pulmonology, University Hospital Heidelberg, Heidelberg, Germany, 8Diagnostic and Interventional Radiology, Hufeland Hospital, Bad Langensalza, Germany

The objective of this study was to investigate the 4-week repeatability of contrast-agent based pulmonary perfusion quantification in clinically stable patients with COPD and CF. Software including fully automated lung segmentation was used to determine pulmonary blood flow (PBF). While a good agreement of PBF was found in the majority of patients, high variabilities were found. Several influence factors were considered as explanations. Differences in SNR due to different inspiratory levels are likely to influence whether quantification in each voxel succeeds. Thus, it may be necessary to modify voxel-based quantification to compensate for differences in inspiratory levels and low SNR.

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