The aim of this study was to estimate the diagnostic accuracy of DCE-MR in the differential diagnosis between malignant and benign pulmonary lesions. Thirty patients with suspected lung cancer were recruited. 13 malignancies were proved by pathology. The DCE-MR data was acquired with the TWIST-VIBE technique, and quantitative parameters (Ktrans, Kep, and Ve) were calculated by the Tofts model. Our results demonstrated that malignant lesions had significant higher Ktrans and kep values than benign lesions. The Ktrans and Kep derived from DCE-MR are promising quantification parameters for differentiating lung lesions.