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Abstract #2483

MRI assessed small bowel dysmotility and its relationship with patient reported symptoms: An exploration of automated vs subjective assessment techniques

Ruaridh Malcolm Gollifer1, Alex Menys1, Andrew Plumb1, Frans Vos2,3, Jaap Stoker2, Stuart A Taylor1, and David Atkinson1

1Centre for Medical Imaging, University College London (UCL), London, United Kingdom, 2Radiology and Nuclear Medicine, Academic Medical Center (AMC), Amsterdam, Netherlands, 3Quantitative Imaging Group, Delft University of Technology, Delft, Netherlands

The pathophysiology of chronic abdominal symptoms in Crohn’s disease (CD) is complex. Recent pilot data using automated quantification of motility MRI suggests reduced variation in apparently normal bowel may underpin symptoms, including pain and diarrhoea. This two-centre validation study tests this association and compares automated measurements with subjective radiologist bowel motility assessment. We confirmed that reduced spatial variation of motility is significantly associated with the severity of abdominal symptoms, although the correlation was not strong. Automated measurement had superior inter-reader variability than subjective radiologist assessment, and showed a stronger association with patient symptoms.

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